Inventory: So many ways to organize it!

[Soala]

The inventory, one of the most important feature found in so many games.
Some may call it a bag, an inventory, an item menu or whatsoever.

It's that time again, and I need to design one. No matter what it must have (tabs, categories, and such) I am still confused by how I should organize it.
The way it is made will make the user accomplish various actions in order to use it properly.

The real question, then, is: How would you like to handle your items and easily access them?

There are just too many ways to organize an inventory, create tabs or categories or eventualy seperate everything into multiple keys.

What sounds best? And why?
Do you prefer aesthetic over use?